MolNFT v1 · #142692 · protein
Structure of leucine dehydrogenase from geobacillus stearothermophilus by cryo-EM
6ACF: “Structure of leucine dehydrogenase from geobacillus stearothermophilus by cryo-EM”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #142692 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ACF
- Type
- protein
- Length
- 2,936 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine dehydrogenase
- UniProt
- A0A0K2HC96
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 1 distinct chain · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Leucine dehydrogenase | protein | 367 | 44% helix, 16% strand | A0A0K2HC96 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 971 | 0.87 | 0.89 | 122 | empty |
| 2 | 1116 | 0.86 | 0.87 | 124 | empty |
| 3 | 1094 | 0.84 | 0.85 | 95 | empty |
| 4 | 1062 | 0.83 | 0.84 | 94 | empty |
| 5 | 660 | 0.76 | 0.82 | 68 | empty |
Interfaces
16 interfaces between chains.
- E–F · 1347 Ų buried · 17 hydrogen bonds · protein-protein
- G–H · 1347 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 1344 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 1344 Ų buried · 17 hydrogen bonds · protein-protein
- E–G · 1264 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 6ACF · structure of leucine dehydrogenase from Geobacillus stearothermophilus by cryo-EM · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0K2HC96
- Elsewhere: RCSB PDB 6ACF · PDBe 6ACF · UniProt A0A0K2HC96
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.