MolNFT v1 · #142687 · protein

Crystal structure of mycobacterium tuberculosis mfd at 3.6 a resolution

6ACA: “Crystal structure of mycobacterium tuberculosis mfd at 3.6 a resolution”. X-ray diffraction, 16 pockets (best druggability 0.86). MolNFT v1 #142687 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6ACA
Type: protein
Length: 1,133 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mycobacterium tuberculosis mfd
EC: 3.6.4.-
UniProt: P9WMQ5
Pockets: 16 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mycobacterium tuberculosis mfd (EC 3.6.4.-)	protein	1133	38% helix, 15% strand	P9WMQ5

Pockets

16 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	943	0.86	0.88	107	empty
2	906	0.78	0.81	102	empty
3	233	0.74	0.88	35	empty
4	57	0.70	0.97	22	empty
5	552	0.68	0.78	54	empty

Compared structures

6ACA · Crystal structure of Mycobacterium tuberculosis Mfd at 3.6 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
P9WMQ5 · AlphaFold monomer V2.0 prediction for transcription-repair-coupling factor (P9WMQ5) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P9WMQ5
Elsewhere: RCSB PDB 6ACA · PDBe 6ACA · UniProt P9WMQ5

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