MolNFT v1 · #142680 · protein
Structure of a natural red emitting luciferase from phrixothrix hirtus (P3121 crystal form)
6AC3 · Red-bioluminescence eliciting luciferase: “Structure of a natural red emitting luciferase from phrixothrix hirtus (P3121 crystal form)”. X-ray diffraction, 20 pockets (best druggability 0.83). MolNFT v1 #142680 on GenesisL1: 3D…
- PDB
- 6AC3
- Type
- protein
- Length
- 1,780 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Red-bioluminescence eliciting luciferase
- UniProt
- Q9U4U7
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 4 distinct chains · 29% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Red-bioluminescence eliciting luciferase | protein | 419 | 30% helix, 17% strand | Q9U4U7 |
| B | Red-bioluminescence eliciting luciferase | protein | 528 | 28% helix, 16% strand | Q9U4U7 |
| C | Red-bioluminescence eliciting luciferase | protein | 417 | 29% helix, 18% strand | Q9U4U7 |
| D | Red-bioluminescence eliciting luciferase | protein | 416 | 30% helix, 19% strand | Q9U4U7 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 783 | 0.83 | 0.85 | 55 | empty |
| 2 | 804 | 0.82 | 0.85 | 56 | empty |
| 3 | 282 | 0.78 | 0.90 | 40 | empty |
| 4 | 234 | 0.76 | 0.90 | 38 | empty |
| 5 | 249 | 0.76 | 0.89 | 35 | empty |
Interfaces
5 interfaces between chains.
- B–C · 968 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 953 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 526 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 153 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 125 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6AC3 · Structure of a natural red emitting luciferase from Phrixothrix hirtus (P3121 crystal… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9U4U7
- Elsewhere: RCSB PDB 6AC3 · PDBe 6AC3 · UniProt Q9U4U7
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