MolNFT v1 · #142665 · protein
Human XRCC4 and IFFO1 complex
6ABO · DNA repair protein XRCC4: “Human XRCC4 and IFFO1 complex”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.34). MolNFT v1 #142665 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ABO
- Type
- protein
- Length
- 290 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA repair protein XRCC4; Intermediate filament family orphan 1
- UniProt
- Q13426, Q0D2I5
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA repair protein XRCC4 | protein | 213 | 55% helix, 24% strand | Q13426 |
| B | Intermediate filament family orphan 1 | protein | 77 | 94% helix, 0% strand | Q0D2I5 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 82 | 0.34 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1404 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6ABO · human XRCC4 and IFFO1 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q13426 · AlphaFold monomer V2.0 prediction for DNA repair protein XRCC4 (Q13426) · a predicted model of the same protein · chain A against A, TM-score 0.86
- Q0D2I5 · AlphaFold monomer V2.0 prediction for non-homologous end joining factor IFFO1 (Q0D2I5) · a predicted model of the same protein · chain B against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13426
- Every structure of UniProt Q0D2I5
- Elsewhere: RCSB PDB 6ABO · PDBe 6ABO · UniProt Q13426 · UniProt Q0D2I5
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