MolNFT v1 · #142608 · protein

Crystal structure of the human glial fibrillary acidic protein 1B domain

6A9P: “Crystal structure of the human glial fibrillary acidic protein 1B domain”. X-ray diffraction, 10 pockets (best druggability 0.48). MolNFT v1 #142608 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6A9P
Type: protein
Length: 820 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glial fibrillary acidic protein
UniProt: P14136
Pockets: 10 · best druggability 0.48

Structure

x-ray diffraction · 6 distinct chains · 97% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, G	Glial fibrillary acidic protein	protein	103	97% helix, 0% strand	P14136
C	Glial fibrillary acidic protein	protein	104	96% helix, 0% strand	P14136
D	Glial fibrillary acidic protein	protein	104	97% helix, 0% strand	P14136
E	Glial fibrillary acidic protein	protein	102	98% helix, 0% strand	P14136
F	Glial fibrillary acidic protein	protein	100	98% helix, 0% strand	P14136
H	Glial fibrillary acidic protein	protein	101	98% helix, 0% strand	P14136

Pockets

10 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	189	0.48	0.76	28	empty
2	141	0.48	0.78	21	empty
3	90	0.43	0.79	18	empty
4	134	0.43	0.76	22	empty
5	157	0.42	0.74	22	empty

Interfaces

12 interfaces between chains.

C–D · 2972 Å² buried · 9 hydrogen bonds · protein-protein
A–B · 2849 Å² buried · 11 hydrogen bonds · protein-protein
G–H · 2807 Å² buried · 10 hydrogen bonds · protein-protein
E–F · 2789 Å² buried · 13 hydrogen bonds · protein-protein
C–E · 800 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

6A9P · Crystal structure of the human glial fibrillary acidic protein 1B domain · the same entry in another collection · chain H against H, TM-score 1.00
P14136 · AlphaFold monomer V2.0 prediction for glial fibrillary acidic protein (P14136) · a predicted model of the same protein · chain F against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14136
Elsewhere: RCSB PDB 6A9P · PDBe 6A9P · UniProt P14136

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