MolNFT v1 · #142583 · protein

Phoq sensor domain (D179R mutant): analysis of internal cavity

6A8V · Sensor protein phoq: “Phoq sensor domain (D179R mutant): analysis of internal cavity”. X-ray diffraction, 1 pocket (best druggability 0.54). MolNFT v1 #142583 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6A8V
Type: protein
Length: 278 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sensor protein phoq
EC: 2.7.13.3, 3.1.3.-
UniProt: P23837
Pockets: 1 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sensor protein phoq (EC 2.7.13.3, 3.1.3.-)	protein	140	36% helix, 30% strand	P23837
B	Sensor protein phoq (EC 2.7.13.3, 3.1.3.-)	protein	138	36% helix, 30% strand	P23837

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	199	0.54	0.78	29	empty

Interfaces

1 interface between chains.

A–B · 525 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6A8V · PhoQ sensor domain (D179R mutant): analysis of internal cavity · the same entry in another collection · chain A against A, TM-score 1.00
P23837 · AlphaFold monomer V2.0 prediction for sensor protein phoq (P23837) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23837
Elsewhere: RCSB PDB 6A8V · PDBe 6A8V · UniProt P23837

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