MolNFT v1 · #142552 · protein

Structure of a catalytic domain of the colistin resistance enzyme

6A7W · Putative integral membrane protein: “Structure of a catalytic domain of the colistin resistance enzyme”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.77). MolNFT v1 #142552 on GenesisL1: 3D structure, binding…

PDB: 6A7W
Type: protein
Length: 648 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative integral membrane protein
UniProt: A0A1C3NEV1
Ligands: ZN
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Putative integral membrane protein	protein	324	30% helix, 16% strand	A0A1C3NEV1

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1037	0.77	0.79	88	empty
2	50	0.56	0.91	21	empty

Interfaces

1 interface between chains.

A–B · 425 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

6A7W · Structure of a catalytic domain of the colistin resistance enzyme · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A1C3NEV1
Elsewhere: RCSB PDB 6A7W · PDBe 6A7W · UniProt A0A1C3NEV1

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