MolNFT v1 · #142527 · protein
Crystal structure of ASF1 from plasmodium falciparum
6A6Y · Histone chaperone ASF1, putative: “Crystal structure of ASF1 from plasmodium falciparum”. X-ray diffraction, 1 ligand (SCN), 2 pockets (best druggability 0.57). MolNFT v1 #142527 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6A6Y
- Type
- protein
- Length
- 303 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone chaperone ASF1, putative
- UniProt
- Q8I5H2
- Ligands
- SCN
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone chaperone ASF1, putative | protein | 152 | 9% helix, 53% strand | Q8I5H2 |
| B | Histone chaperone ASF1, putative | protein | 151 | 9% helix, 54% strand | Q8I5H2 |
Ligands and binding sites
- SCN · Thiocyanate ion · ion · 6 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 199 | 0.57 | 0.80 | 32 | SCN |
| 2 | 216 | 0.48 | 0.74 | 23 | SCN |
Interfaces
1 interface between chains.
- A–B · 602 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6A6Y · Crystal Structure of Asf1 from Plasmodium falciparum · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8I5H2
- Elsewhere: RCSB PDB 6A6Y · PDBe 6A6Y · UniProt Q8I5H2
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