MolNFT v1 · #142396 · protein
Crystal structure of MUNC13-1 mun domain and synaptobrevin-2 juxtamembrane linker region
6A30 · Protein unc-13 homolog a: “Crystal structure of MUNC13-1 mun domain and synaptobrevin-2 juxtamembrane linker region”. X-ray diffraction, 3 pockets (best druggability 0.41). MolNFT v1 #142396 on GenesisL1: 3D structure, binding sites…
- PDB
- 6A30
- Type
- protein
- Length
- 533 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein unc-13 homolog a; Synaptobrevin-2 juxtamembrane linker peptide
- UniProt
- Q62768, P63045
- Pockets
- 3 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein unc-13 homolog a | protein | 527 | 70% helix, 1% strand | Q62768 |
| P | Synaptobrevin-2 juxtamembrane linker peptide | protein | 6 | 0% helix, 0% strand | P63045 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 124 | 0.41 | 0.76 | 21 | empty |
| 2 | 72 | 0.39 | 0.78 | 17 | empty |
| 3 | 50 | 0.28 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–P · 323 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6A30 · Crystal Structure of Munc13-1 MUN Domain and Synaptobrevin-2 Juxtamembrane Linker Region · the same entry in another collection · chain A against A, TM-score 1.00
- Q62768 · AlphaFold monomer V2.0 prediction for protein unc-13 homolog a (Q62768) · a predicted model of the same protein · chain A against A, TM-score 0.94
- P63045 · AlphaFold monomer V2.0 prediction for vesicle-associated membrane protein 2 (P63045) · a predicted model of the same protein · chain P against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62768
- Every structure of UniProt P63045
- Elsewhere: RCSB PDB 6A30 · PDBe 6A30 · UniProt Q62768 · UniProt P63045
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