MolNFT v1 · #142333 · protein
Mandelate oxidase mutant-Y128F with phenylpyruvic acid
6A11 · 4-hydroxymandelate oxidase: “Mandelate oxidase mutant-Y128F with phenylpyruvic acid”. X-ray diffraction, 2 ligands (FMN, PPY), 4 pockets (best druggability 0.75). MolNFT v1 #142333 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6A11
- Type
- protein
- Length
- 334 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 4-hydroxymandelate oxidase
- EC
- 1.1.3.46
- UniProt
- O52792
- Ligands
- FMN, PPY
- Pockets
- 4 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 4-hydroxymandelate oxidase (EC 1.1.3.46) | protein | 334 | 45% helix, 15% strand | O52792 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 318 | 0.75 | 0.86 | 49 | FMN, PPY |
| 2 | 115 | 0.38 | 0.74 | 23 | empty |
| 3 | 67 | 0.35 | 0.77 | 15 | empty |
| 4 | 50 | 0.28 | 0.75 | 11 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O52792
- Elsewhere: RCSB PDB 6A11 · PDBe 6A11 · UniProt O52792
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