MolNFT v1 · #142085 · protein
Nifs from hydrogenimonas thermophila
5ZSP · Cysteine desulfurase: “Nifs from hydrogenimonas thermophila”. X-ray diffraction, 9 pockets (best druggability 0.80). MolNFT v1 #142085 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ZSP
- Type
- protein
- Length
- 770 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine desulfurase
- UniProt
- A0A1I5NEH3
- Pockets
- 9 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine desulfurase | protein | 388 | 39% helix, 19% strand | A0A1I5NEH3 |
| B | Cysteine desulfurase | protein | 382 | 41% helix, 19% strand | A0A1I5NEH3 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 180 | 0.80 | 0.95 | 25 | empty |
| 2 | 95 | 0.76 | 0.98 | 21 | empty |
| 3 | 334 | 0.62 | 0.79 | 48 | empty |
| 4 | 317 | 0.60 | 0.78 | 42 | empty |
| 5 | 94 | 0.35 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 2492 Ų buried · 35 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (cofactor).
Compared structures
- 5ZSP · NifS from Hydrogenimonas thermophila · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1I5NEH3
- Elsewhere: RCSB PDB 5ZSP · PDBe 5ZSP · UniProt A0A1I5NEH3
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