MolNFT v1 · #142040 · protein

Manganese-dependent transcriptional repressor complex with manganese

5ZR6 · Metal-dependent transcriptional regulator: “Manganese-dependent transcriptional repressor complex with manganese”. X-ray diffraction, 1 ligand (MN), 3 pockets (best druggability 0.76). MolNFT v1 #142040 on GenesisL1: 3D structure…

PDB: 5ZR6
Type: protein
Length: 424 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Metal-dependent transcriptional regulator
UniProt: A0A045JFF4
Ligands: MN
Pockets: 3 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Metal-dependent transcriptional regulator	protein	214	41% helix, 18% strand	A0A045JFF4
B	Metal-dependent transcriptional regulator	protein	210	45% helix, 17% strand	A0A045JFF4

Ligands and binding sites

MN · Manganese (II) ion · metal · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	62	0.76	0.99	16	empty
2	291	0.60	0.79	38	empty
3	258	0.57	0.78	28	MN

Interfaces

1 interface between chains.

A–B · 816 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

5ZR6 · Manganese-dependent transcriptional repressor complex with manganese · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A045JFF4
Elsewhere: RCSB PDB 5ZR6 · PDBe 5ZR6 · UniProt A0A045JFF4

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