MolNFT v1 · #142039 · protein
Manganese-dependent transcriptional repressor
5ZR4 · Metal-dependent transcriptional regulator: “Manganese-dependent transcriptional repressor”. X-ray diffraction, 3 pockets (best druggability 0.76). MolNFT v1 #142039 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ZR4
- Type
- protein
- Length
- 365 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Metal-dependent transcriptional regulator
- UniProt
- A0A045JFF4
- Pockets
- 3 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Metal-dependent transcriptional regulator | protein | 184 | 40% helix, 18% strand | A0A045JFF4 |
| B | Metal-dependent transcriptional regulator | protein | 181 | 38% helix, 18% strand | A0A045JFF4 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.76 | 0.99 | 17 | empty |
| 2 | 175 | 0.49 | 0.77 | 25 | empty |
| 3 | 137 | 0.48 | 0.79 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 822 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 5ZR4 · Manganese-dependent transcriptional repressor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A045JFF4
- Elsewhere: RCSB PDB 5ZR4 · PDBe 5ZR4 · UniProt A0A045JFF4
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