MolNFT v1 · #142021 · protein
Crystal structure of human katanin aaa ATPase domain
5ZQL · Katanin P60 ATPase-containing subunit A1: “Crystal structure of human katanin aaa ATPase domain”. X-ray diffraction, 10 pockets (best druggability 0.71). MolNFT v1 #142021 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5ZQL
- Type
- protein
- Length
- 510 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Katanin P60 ATPase-containing subunit A1
- EC
- 3.6.4.3
- UniProt
- O75449
- Pockets
- 10 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Katanin P60 ATPase-containing subunit A1 (EC 3.6.4.3) | protein | 258 | 52% helix, 10% strand | O75449 |
| A | Katanin P60 ATPase-containing subunit A1 (EC 3.6.4.3) | protein | 252 | 51% helix, 10% strand | O75449 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.71 | 0.98 | 16 | empty |
| 2 | 50 | 0.65 | 0.95 | 21 | empty |
| 3 | 204 | 0.64 | 0.83 | 32 | empty |
| 4 | 71 | 0.59 | 0.89 | 18 | empty |
| 5 | 175 | 0.53 | 0.78 | 28 | empty |
Interfaces
1 interface between chains.
- B–A · 698 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5ZQL · crystal structure of human katanin AAA ATPase domain · the same entry in another collection · chain B against B, TM-score 1.00
- O75449 · AlphaFold monomer V2.0 prediction for katanin P60 ATPase-containing subunit A1 (O75449) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75449
- Elsewhere: RCSB PDB 5ZQL · PDBe 5ZQL · UniProt O75449
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