MolNFT v1 · #141954 · protein
Crystal structure of ALPHA1,3-fucosyltransferase
5ZOI · Alpha-(1,3)-fucosyltransferase fuct: “Crystal structure of ALPHA1,3-fucosyltransferase”. X-ray diffraction, 1 ligand (C06), 9 pockets (best druggability 0.78). MolNFT v1 #141954 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5ZOI
- Type
- protein
- Length
- 686 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-(1,3)-fucosyltransferase fuct
- EC
- 2.4.1.152
- UniProt
- O30511
- Ligands
- C06
- Pockets
- 9 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Alpha-(1,3)-fucosyltransferase fuct (EC 2.4.1.152) | protein | 343 | 28% helix, 13% strand | O30511 |
Ligands and binding sites
- C06 · [[(2S,3R,4S,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2S,3S,4S,5R,6R)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl] hydrogen phosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 509 | 0.78 | 0.85 | 69 | C06 |
| 2 | 196 | 0.68 | 0.86 | 29 | empty |
| 3 | 83 | 0.52 | 0.85 | 18 | empty |
| 4 | 58 | 0.38 | 0.80 | 17 | empty |
| 5 | 87 | 0.37 | 0.76 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 888 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 covalent (covalent ligand).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O30511
- Elsewhere: RCSB PDB 5ZOI · PDBe 5ZOI · UniProt O30511
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