MolNFT v1 · #141890 · protein
Crystal structure of the Fab region of a neutralizing fully human antibody against gm-csf
5ZMJ · Heavy chain of a Fab fraction of human IgG: “Crystal structure of the Fab region of a neutralizing fully human antibody against gm-csf”. X-ray diffraction, 2 ligands (NA, SO4), 3 pockets (best druggability 0.72). MolNFT v1 #141890…
- PDB
- 5ZMJ
- Type
- protein
- Length
- 438 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heavy chain of a Fab fraction of human IgG; Light chain of a Fab fraction of human IgG
- Ligands
- NA, SO4
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Heavy chain of a Fab fraction of human IgG | protein | 227 | 9% helix, 48% strand | — |
| L | Light chain of a Fab fraction of human IgG | protein | 211 | 8% helix, 50% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 952 | 0.72 | 0.76 | 81 | NA |
| 2 | 86 | 0.43 | 0.80 | 19 | empty |
| 3 | 96 | 0.36 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- H–L · 2157 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5ZMJ · Crystal structure of the Fab region of a neutralizing fully human antibody against GM-CSF · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5ZMJ · PDBe 5ZMJ
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.