MolNFT v1 · #141846 · protein

The postfusion structure of human-infecting bourbon virus envelope glycoprotein

5ZKX: “The postfusion structure of human-infecting bourbon virus envelope glycoprotein”. X-ray diffraction, 12 pockets (best druggability 0.47). MolNFT v1 #141846 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5ZKX
Type: protein
Length: 1,158 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Envelope glycoprotein
UniProt: A0A140H4W8
Pockets: 12 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Envelope glycoprotein	protein	388	22% helix, 33% strand	A0A140H4W8
C	Envelope glycoprotein	protein	382	24% helix, 32% strand	A0A140H4W8

Pockets

12 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	172	0.47	0.76	21	empty
2	161	0.45	0.75	17	empty
3	84	0.44	0.80	18	empty
4	147	0.40	0.74	20	empty
5	76	0.34	0.76	22	empty

Interfaces

2 interfaces between chains.

A–B · 205 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 79 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 15 disulfide (disulfide).

Compared structures

5ZKX · The postfusion structure of human-infecting Bourbon virus envelope glycoprotein · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A140H4W8
Elsewhere: RCSB PDB 5ZKX · PDBe 5ZKX · UniProt A0A140H4W8

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