MolNFT v1 · #141763 · protein
Crystal structure of human anti-tau antibody cbtau-24.1 in complex with its phosphorylated tau peptide
5ZIA · Heavy chain of cbtau-24.1 antibody: “Crystal structure of human anti-tau antibody cbtau-24.1 in complex with its phosphorylated tau peptide”. X-ray diffraction, 20 pockets (best druggability 0.61). MolNFT v1 #141763 on GenesisL1: 3D…
- PDB
- 5ZIA
- Type
- protein
- Length
- 2,675 residues
- Chains
- 18
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heavy chain of cbtau-24.1 antibody; Light chain (kappa) of cbtau-24.1 antibody…
- Pockets
- 20 · best druggability 0.61
Structure
x-ray diffraction · 6 distinct chains · 6% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G, A, K, O | Heavy chain of cbtau-24.1 antibody | protein | 220 | 7% helix, 48% strand | — |
| L, I, M, P | Light chain (kappa) of cbtau-24.1 antibody | protein | 217 | 5% helix, 53% strand | — |
| R, C, F, J, N, Q | Phosphorylated tau peptide | protein | 9 | 0% helix, 0% strand | — |
| B | Light chain (kappa) of cbtau-24.1 antibody | protein | 217 | 5% helix, 53% strand | — |
| D, H | Heavy chain of cbtau-24.1 antibody | protein | 219 | 7% helix, 49% strand | — |
| E | Light chain (kappa) of cbtau-24.1 antibody | protein | 218 | 5% helix, 51% strand | — |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 177 | 0.61 | 0.83 | 43 | empty |
| 2 | 135 | 0.60 | 0.85 | 34 | empty |
| 3 | 56 | 0.58 | 0.91 | 19 | empty |
| 4 | 171 | 0.56 | 0.80 | 28 | empty |
| 5 | 78 | 0.55 | 0.87 | 22 | empty |
Interfaces
48 interfaces between chains.
- G–L · 1775 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1774 Ų buried · 12 hydrogen bonds · protein-protein
- D–E · 1763 Ų buried · 13 hydrogen bonds · protein-protein
- H–I · 1747 Ų buried · 11 hydrogen bonds · protein-protein
- O–P · 1734 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 disulfide, 6 modified (disulfide, phosphorylation).
Compared structures
- 5ZIA · Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its… · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5ZIA · PDBe 5ZIA
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