MolNFT v1 · #141734 · protein
Structure of inositol monophosphatase from anabaena (nostoc) sp. pcc 7120
5ZHH · Inositol-1-monophosphatase: “Structure of inositol monophosphatase from anabaena (nostoc) sp. pcc 7120”. X-ray diffraction, 14 pockets (best druggability 0.78). MolNFT v1 #141734 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5ZHH
- Type
- protein
- Length
- 985 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inositol-1-monophosphatase
- EC
- 3.1.3.25
- UniProt
- Q8YT10
- Pockets
- 14 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 39% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inositol-1-monophosphatase (EC 3.1.3.25) | protein | 252 | 38% helix, 25% strand | Q8YT10 |
| B | Inositol-1-monophosphatase (EC 3.1.3.25) | protein | 242 | 38% helix, 24% strand | Q8YT10 |
| C | Inositol-1-monophosphatase (EC 3.1.3.25) | protein | 246 | 40% helix, 25% strand | Q8YT10 |
| D | Inositol-1-monophosphatase (EC 3.1.3.25) | protein | 245 | 40% helix, 24% strand | Q8YT10 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 115 | 0.78 | 0.97 | 24 | empty |
| 2 | 112 | 0.78 | 0.97 | 24 | empty |
| 3 | 641 | 0.71 | 0.78 | 50 | empty |
| 4 | 158 | 0.63 | 0.85 | 31 | empty |
| 5 | 215 | 0.63 | 0.83 | 39 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1750 Ų buried · 27 hydrogen bonds · protein-protein
- A–B · 1672 Ų buried · 28 hydrogen bonds · protein-protein
- A–C · 664 Ų buried · 14 hydrogen bonds · protein-protein
- B–D · 644 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 5ZHH · Structure of Inositol monophosphatase from Anabaena (Nostoc) sp. PCC 7120 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8YT10
- Elsewhere: RCSB PDB 5ZHH · PDBe 5ZHH · UniProt Q8YT10
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