MolNFT v1 · #141701 · protein
NMR structure of P75NTR transmembrane domain in complex with NSC49652
5ZGG · Tumor necrosis factor receptor superfamily member 16: “NMR structure of P75NTR transmembrane domain in complex with NSC49652”. Solution nmr, 1 ligand (9F6), 1 pocket (best druggability 0.42). MolNFT v1 #141701 on GenesisL1: 3D…
- PDB
- 5ZGG
- Type
- protein
- Length
- 68 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor necrosis factor receptor superfamily member 16
- UniProt
- P08138
- Ligands
- 9F6
- Pockets
- 1 · best druggability 0.42
Structure
solution nmr · 1 distinct chain · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Tumor necrosis factor receptor superfamily member 16 | protein | 34 | 74% helix, 0% strand | P08138 |
Ligands and binding sites
- 9F6 · (2E)-1-(2-hydroxyphenyl)-3-(pyridin-3-yl)prop-2-en-1-one · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 88 | 0.42 | 0.78 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 370 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5ZGG · NMR structure of p75NTR transmembrane domain in complex with NSC49652 · the same entry in another collection · chain A against A, TM-score 1.00
- P08138 · AlphaFold monomer V2.0 prediction for tumor necrosis factor receptor superfamily member… · a predicted model of the same protein · chain A against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08138
- Elsewhere: RCSB PDB 5ZGG · PDBe 5ZGG · UniProt P08138
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