MolNFT v1 · #1417 · protein

The crystal structure of phosphoglucose isomerase-an enzyme with autocrine motility factor activity in tumor cells

1B0Z · Protein (phosphoglucose isomerase): “The crystal structure of phosphoglucose isomerase-an enzyme with autocrine motility factor activity in tumor…”. X-ray diffraction, 4 pockets (best druggability 0.56). MolNFT v1 #1417 on…

PDB: 1B0Z
Type: protein
Length: 442 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (phosphoglucose isomerase)
EC: 5.3.1.9
UniProt: P13376
Pockets: 4 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (phosphoglucose isomerase) (EC 5.3.1.9)	protein	442	54% helix, 14% strand	P13376

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	292	0.56	0.76	38	empty
2	140	0.48	0.78	22	empty
3	112	0.45	0.78	19	empty
4	62	0.34	0.77	13	empty

Compared structures

1B0Z · The crystal structure of phosphoglucose isomerase-an enzyme with autocrine motility… · the same entry in another collection · chain A against A, TM-score 1.00
P13376 · AlphaFold monomer V2.0 prediction for glucose-6-phosphate isomerase B (P13376) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13376
Elsewhere: RCSB PDB 1B0Z · PDBe 1B0Z · UniProt P13376

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