MolNFT v1 · #141691 · protein
Crystal structure of triosephosphate isomerase sadsubaaa mutant from opisthorchis viverrini
5ZG5: “Crystal structure of triosephosphate isomerase sadsubaaa mutant from opisthorchis viverrini”. X-ray diffraction, 5 pockets (best druggability 0.75). MolNFT v1 #141691 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ZG5
- Type
- protein
- Length
- 496 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Triosephosphate isomerase
- EC
- 5.3.1.1
- UniProt
- A0A074Z863
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Triosephosphate isomerase (EC 5.3.1.1) | protein | 248 | 46% helix, 16% strand | A0A074Z863 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.75 | 0.97 | 26 | empty |
| 2 | 119 | 0.46 | 0.78 | 29 | empty |
| 3 | 72 | 0.41 | 0.80 | 21 | empty |
| 4 | 111 | 0.41 | 0.76 | 22 | empty |
| 5 | 87 | 0.38 | 0.76 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1694 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 5ZG5 · Crystal Structure of Triosephosphate isomerase SADsubAAA mutant from Opisthorchis… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A074Z863
- Elsewhere: RCSB PDB 5ZG5 · PDBe 5ZG5 · UniProt A0A074Z863
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