MolNFT v1 · #141667 · protein
Crystal structure of a diazinon-metabolizing glutathione S-transferase in the silkworm, bombyx mori
5ZFG: “Crystal structure of a diazinon-metabolizing glutathione S-transferase in the silkworm, bombyx mori”. X-ray diffraction, 5 pockets (best druggability 0.57). MolNFT v1 #141667 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5ZFG
- Type
- protein
- Length
- 405 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutathione S-transferase
- UniProt
- A9XI30
- Pockets
- 5 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutathione S-transferase | protein | 202 | 60% helix, 9% strand | A9XI30 |
| B | Glutathione S-transferase | protein | 203 | 59% helix, 8% strand | A9XI30 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 4 copies · chains A, B
- ACT · Acetate ion · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 269 | 0.57 | 0.77 | 33 | ACT |
| 2 | 241 | 0.56 | 0.78 | 31 | ACT |
| 3 | 95 | 0.47 | 0.81 | 15 | EDO |
| 4 | 85 | 0.45 | 0.80 | 16 | empty |
| 5 | 67 | 0.35 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1319 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 5ZFG · Crystal structure of a diazinon-metabolizing glutathione S-transferase in the silkworm… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A9XI30
- Elsewhere: RCSB PDB 5ZFG · PDBe 5ZFG · UniProt A9XI30
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.