MolNFT v1 · #141599 · protein

DSM5389 glycosyltrehalose synthase

5ZCR · Maltooligosyl trehalose synthase: “DSM5389 glycosyltrehalose synthase”. X-ray diffraction, 1 ligand (MG), 14 pockets (best druggability 0.76). MolNFT v1 #141599 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5ZCR
Type: protein
Length: 1,450 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Maltooligosyl trehalose synthase
UniProt: Q7LYV2
Ligands: MG
Pockets: 14 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Maltooligosyl trehalose synthase	protein	725	45% helix, 15% strand	Q7LYV2

Ligands and binding sites

MG · Magnesium ion · metal · 2 copies · chains A, B
GOL · Glycerol · additive · 11 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	796	0.76	0.80	63	MG, GOL
2	1032	0.76	0.78	108	empty
3	799	0.75	0.80	67	MG, GOL
4	699	0.75	0.80	81	empty
5	422	0.61	0.76	41	empty

Interfaces

1 interface between chains.

A–B · 395 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5ZCR · DSM5389 glycosyltrehalose synthase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7LYV2
Elsewhere: RCSB PDB 5ZCR · PDBe 5ZCR · UniProt Q7LYV2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.