MolNFT v1 · #141511 · protein + RNA
Ebola virus nucleoprotein-RNA complex
5Z9W · Ebolavirus nucleoprotein (residues 19-406): “Ebola virus nucleoprotein-RNA complex”. Electron microscopy, 9 pockets (best druggability 0.63). MolNFT v1 #141511 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5Z9W
- Type
- protein + RNA
- Length
- 394 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ebolavirus nucleoprotein (residues 19-406); RNA (6-mer)
- Pockets
- 9 · best druggability 0.63
Structure
electron microscopy · 2 distinct chains · 62% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ebolavirus nucleoprotein (residues 19-406) | protein | 388 | 62% helix, 5% strand | — |
| R | RNA (6-mer) | rna | 6 | — | — |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 100 | 0.63 | 0.89 | 19 | empty |
| 2 | 245 | 0.55 | 0.77 | 28 | empty |
| 3 | 74 | 0.53 | 0.86 | 19 | empty |
| 4 | 162 | 0.47 | 0.77 | 18 | empty |
| 5 | 86 | 0.47 | 0.81 | 13 | empty |
Interfaces
1 interface between chains.
- A–R · 804 Ų buried · 9 hydrogen bonds · protein-nucleic
Compared structures
- 5Z9W · Ebola virus nucleoprotein-RNA complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5Z9W · PDBe 5Z9W
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