MolNFT v1 · #141479 · protein

Human mitochondrial ferritin mutant - C102A/C130A

5Z8U · Ferritin, mitochondrial: “Human mitochondrial ferritin mutant - C102A/C130A”. X-ray diffraction, 1 ligand (MG), 1 pocket (best druggability 0.69). MolNFT v1 #141479 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5Z8U
Type: protein
Length: 342 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ferritin, mitochondrial
EC: 1.16.3.1
UniProt: Q8N4E7
Ligands: MG
Pockets: 1 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 74% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ferritin, mitochondrial (EC 1.16.3.1)	protein	171	74% helix, 1% strand	Q8N4E7

Ligands and binding sites

MG · Magnesium ion · metal · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	154	0.69	0.88	22	empty

Interfaces

1 interface between chains.

A–B · 1445 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

5Z8U · Human mitochondrial ferritin mutant - C102A/C130A · the same entry in another collection · chain A against A, TM-score 1.00
Q8N4E7 · AlphaFold monomer V2.0 prediction for ferritin, mitochondrial (Q8N4E7) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8N4E7
Elsewhere: RCSB PDB 5Z8U · PDBe 5Z8U · UniProt Q8N4E7

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