MolNFT v1 · #141414 · protein

Crystal structure of aaa of spastin

5Z6Q: “Crystal structure of aaa of spastin”. X-ray diffraction, 1 ligand (CL), 3 pockets (best druggability 0.59). MolNFT v1 #141414 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5Z6Q
Type: protein
Length: 272 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spastin
EC: 3.6.4.3
UniProt: Q9UBP0
Ligands: CL
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Spastin (EC 3.6.4.3)	protein	272	49% helix, 11% strand	Q9UBP0

Ligands and binding sites

CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	172	0.59	0.82	30	empty
2	173	0.58	0.81	28	empty
3	150	0.51	0.79	26	empty

Compared structures

5Z6Q · Crystal structure of AAA of Spastin · the same entry in another collection · chain A against A, TM-score 1.00
Q9UBP0 · AlphaFold monomer V2.0 prediction for spastin (Q9UBP0) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UBP0
Elsewhere: RCSB PDB 5Z6Q · PDBe 5Z6Q · UniProt Q9UBP0

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