MolNFT v1 · #141407 · protein
High-pressure crystal structure analysis of M20 loop closed DHFR at 220 mpa
5Z6J · Dihydrofolate reductase: “High-pressure crystal structure analysis of M20 loop closed DHFR at 220 mpa”. X-ray diffraction, 2 ligands (FOL, NAP), 1 pocket (best druggability 0.69). MolNFT v1 #141407 on GenesisL1: 3D structure…
- PDB
- 5Z6J
- Type
- protein
- Length
- 160 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dihydrofolate reductase
- EC
- 1.5.1.3
- UniProt
- P0ABQ4
- Ligands
- FOL, NAP
- Pockets
- 1 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dihydrofolate reductase (EC 1.5.1.3) | protein | 160 | 26% helix, 34% strand | P0ABQ4 |
Ligands and binding sites
- FOL · Folic acid · ligand · chains A
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 296 | 0.69 | 0.84 | 37 | FOL, NAP |
Modifications
Observed in the structure: 1 modified (artifact).
Compared structures
- 5Z6J · High-pressure Crystal Structure Analysis of M20 loop closed DHFR at 220 MPa · the same entry in another collection · chain A against A, TM-score 1.00
- P0ABQ4 · AlphaFold monomer V2.0 prediction for dihydrofolate reductase (P0ABQ4) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ABQ4
- Elsewhere: RCSB PDB 5Z6J · PDBe 5Z6J · UniProt P0ABQ4
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