MolNFT v1 · #141349 · protein + RNA

Structure of tailor in complex with aguu RNA

5Z4D · Terminal uridylyltransferase tailor: “Structure of tailor in complex with aguu RNA”. X-ray diffraction, 2 pockets (best druggability 0.58). MolNFT v1 #141349 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5Z4D
Type: protein + RNA
Length: 355 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Terminal uridylyltransferase tailor; RNA (5'-R(*AP*GP*UP*U)-3')
EC: 2.7.7.52
UniProt: Q9VI58
Pockets: 2 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Terminal uridylyltransferase tailor (EC 2.7.7.52)	protein	351	46% helix, 13% strand	Q9VI58
B	RNA (5'-R(APGPUPU)-3')	rna	4	—	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	243	0.58	0.79	34	empty
2	51	0.32	0.78	12	empty

Interfaces

1 interface between chains.

A–B · 600 Å² buried · 13 hydrogen bonds · protein-nucleic

Compared structures

5Z4D · Structure of Tailor in complex with AGUU RNA · the same entry in another collection · chain A against A, TM-score 1.00
Q9VI58 · AlphaFold monomer V2.0 prediction for terminal uridylyltransferase tailor (Q9VI58) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9VI58
Elsewhere: RCSB PDB 5Z4D · PDBe 5Z4D · UniProt Q9VI58

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