MolNFT v1 · #141290 · protein
Structure of dictyostelium discoideum mitochondrial calcium uniporter N-ternimal domain (se-ddmcu-ntd)
5Z2I: “Structure of dictyostelium discoideum mitochondrial calcium uniporter N-ternimal domain (se-ddmcu-ntd)”. X-ray diffraction, 7 pockets (best druggability 0.60). MolNFT v1 #141290 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5Z2I
- Type
- protein
- Length
- 371 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dictyostelium discoideum mitochondrial calcium uniporter
- UniProt
- Q54LT0
- Pockets
- 7 · best druggability 0.60
Structure
x-ray diffraction · 3 distinct chains · 62% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Dictyostelium discoideum mitochondrial calcium uniporter | protein | 92 | 62% helix, 9% strand | Q54LT0 |
| B | Dictyostelium discoideum mitochondrial calcium uniporter | protein | 94 | 62% helix, 9% strand | Q54LT0 |
| C | Dictyostelium discoideum mitochondrial calcium uniporter | protein | 93 | 62% helix, 9% strand | Q54LT0 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 471 | 0.60 | 0.75 | 53 | empty |
| 2 | 211 | 0.56 | 0.79 | 27 | empty |
| 3 | 112 | 0.48 | 0.80 | 14 | empty |
| 4 | 188 | 0.47 | 0.75 | 23 | empty |
| 5 | 82 | 0.42 | 0.79 | 18 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1447 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 1383 Ų buried · 17 hydrogen bonds · protein-protein
- B–C · 221 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 17 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 5Z2I · Structure of Dictyostelium discoideum mitochondrial calcium uniporter N-ternimal domain… · the same entry in another collection · chain A against A, TM-score 1.00
- Q54LT0 · AlphaFold monomer V2.0 prediction for calcium uniporter protein, mitochondrial (Q54LT0) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q54LT0
- Elsewhere: RCSB PDB 5Z2I · PDBe 5Z2I · UniProt Q54LT0
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