MolNFT v1 · #141232 · protein

Crystal structure of copper-bound H63F-mutated tyrosinase from streptomyces castaneoglobisporus in complex with the caddie protein obtained by soaking in the hydroxylamine-containing solution for 12 H at 298 K

5Z0M: “Crystal structure of copper-bound H63F-mutated tyrosinase from streptomyces castaneoglobisporus in complex…”. X-ray diffraction, 2 ligands (CU, NO3), 1 pocket (best druggability 0.47). MolNFT v1 #141232 on GenesisL1: 3D structure…

PDB: 5Z0M
Type: protein
Length: 346 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosinase; Melc
EC: 1.14.18.1
UniProt: Q83WS2, Q83WS1
Ligands: CU, NO3
Pockets: 1 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosinase (EC 1.14.18.1)	protein	273	41% helix, 5% strand	Q83WS2
B	Melc	protein	73	16% helix, 45% strand	Q83WS1

Ligands and binding sites

CU · Copper (II) ion · metal · 3 copies · chains A, B
NO3 · Nitrate ion · ion · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	122	0.47	0.79	22	empty

Interfaces

1 interface between chains.

A–B · 1086 Å² buried · 19 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (nonstandard).

Compared structures

5Z0M · Crystal structure of copper-bound H63F-mutated tyrosinase from Streptomyces… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q83WS2
Every structure of UniProt Q83WS1
Elsewhere: RCSB PDB 5Z0M · PDBe 5Z0M · UniProt Q83WS2 · UniProt Q83WS1

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