MolNFT v1 · #141230 · protein
Crystal structure of copper-bound tyrosinase from streptomyces castaneoglobisporus in complex with the caddie protein obtained by soaking in the hydroxylamine-containing solution for 4 H at 277 K
5Z0K: “Crystal structure of copper-bound tyrosinase from streptomyces castaneoglobisporus in complex with the caddie…”. X-ray diffraction, 3 ligands (CU, NO3, PER), 2 pockets (best druggability 0.49). MolNFT v1 #141230 on GenesisL1: 3D…
- PDB
- 5Z0K
- Type
- protein
- Length
- 350 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosinase; Melc
- EC
- 1.14.18.1
- UniProt
- Q83WS2, Q83WS1
- Ligands
- CU, NO3, PER
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosinase (EC 1.14.18.1) | protein | 276 | 41% helix, 4% strand | Q83WS2 |
| B | Melc | protein | 74 | 16% helix, 45% strand | Q83WS1 |
Ligands and binding sites
- CU · Copper (II) ion · metal · 4 copies · chains A, B
- NO3 · Nitrate ion · ion · 5 copies · chains A, B
- PER · Peroxide ion · ion · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 121 | 0.49 | 0.80 | 25 | empty |
| 2 | 62 | 0.29 | 0.74 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1053 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (nonstandard).
Compared structures
- 5Z0K · Crystal structure of copper-bound tyrosinase from Streptomyces castaneoglobisporus in… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q83WS2
- Every structure of UniProt Q83WS1
- Elsewhere: RCSB PDB 5Z0K · PDBe 5Z0K · UniProt Q83WS2 · UniProt Q83WS1
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