MolNFT v1 · #141191 · protein
Crystal structure of human crmp-2 with S522D-T509D-T514D-S518D mutations crystallized with GSK3B
5YZB · Dihydropyrimidinase-related protein 2: “Crystal structure of human crmp-2 with S522D-T509D-T514D-S518D mutations crystallized with GSK3B”. X-ray diffraction, 3 pockets (best druggability 0.65). MolNFT v1 #141191 on GenesisL1: 3D…
- PDB
- 5YZB
- Type
- protein
- Length
- 490 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dihydropyrimidinase-related protein 2
- UniProt
- Q16555
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dihydropyrimidinase-related protein 2 | protein | 490 | 34% helix, 23% strand | Q16555 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 194 | 0.65 | 0.85 | 33 | empty |
| 2 | 159 | 0.60 | 0.83 | 21 | empty |
| 3 | 50 | 0.25 | 0.73 | 19 | empty |
Compared structures
- 5YZB · Crystal Structure of Human CRMP-2 with S522D-T509D-T514D-S518D mutations crystallized… · the same entry in another collection · chain A against A, TM-score 1.00
- Q16555 · AlphaFold monomer V2.0 prediction for dihydropyrimidinase-related protein 2 (Q16555) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16555
- Elsewhere: RCSB PDB 5YZB · PDBe 5YZB · UniProt Q16555
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