MolNFT v1 · #14114 · protein

Plasmodium falciparum triosephosphate isomerase (pftim)- phosphoglycolate complex

1LYX: “Plasmodium falciparum triosephosphate isomerase (pftim)- phosphoglycolate complex”. X-ray diffraction, 1 ligand (PGA), 2 pockets (best druggability 0.45). MolNFT v1 #14114 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1LYX
Type: protein
Length: 246 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Triosephosphate isomerase
EC: 5.3.1.1
UniProt: Q07412
Ligands: PGA
Pockets: 2 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Triosephosphate isomerase (EC 5.3.1.1)	protein	246	44% helix, 16% strand	Q07412

Ligands and binding sites

PGA · 2-phosphoglycolic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.45	0.83	22	PGA
2	134	0.44	0.76	25	empty

Compared structures

1LYX · Plasmodium Falciparum Triosephosphate Isomerase (PfTIM)-Phosphoglycolate complex · the same entry in another collection · chain A against A, TM-score 1.00
Q07412 · AlphaFold monomer V2.0 prediction for triosephosphate isomerase (Q07412) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07412
Elsewhere: RCSB PDB 1LYX · PDBe 1LYX · UniProt Q07412

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