MolNFT v1 · #141092 · protein

Crystal structure of unlinked full length NS3 protein (ED4NS2BNS3) from DENV4 in closed conformation

5YVY · Genome polyprotein: “Crystal structure of unlinked full length NS3 protein (ED4NS2BNS3) from DENV4 in closed conformation”. X-ray diffraction, 7 pockets (best druggability 0.81). MolNFT v1 #141092 on GenesisL1: 3D structure, binding…

PDB: 5YVY
Type: protein
Length: 618 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein
UniProt: F8J1V3, F8TEL4
Pockets: 7 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Genome polyprotein	protein	36	0% helix, 17% strand	F8J1V3
B	Genome polyprotein	protein	582	24% helix, 22% strand	F8TEL4

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1169	0.81	0.82	86	empty
2	512	0.70	0.80	50	empty
3	109	0.55	0.84	30	empty
4	164	0.55	0.80	45	empty
5	51	0.50	0.88	17	empty

Interfaces

1 interface between chains.

A–B · 1312 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

5YVY · Crystal structure of unlinked full length NS3 protein (eD4NS2BNS3) from DENV4 in closed… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F8J1V3
Every structure of UniProt F8TEL4
Elsewhere: RCSB PDB 5YVY · PDBe 5YVY · UniProt F8J1V3 · UniProt F8TEL4

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