MolNFT v1 · #141077 · protein

Crystal structure of full length NS2B47-NS3 (GD4NS2BNS3) from dengue virus 4 in open conformation

5YVJ · Genome polyprotein: “Crystal structure of full length NS2B47-NS3 (GD4NS2BNS3) from dengue virus 4 in open conformation”. X-ray diffraction, 4 pockets (best druggability 0.82). MolNFT v1 #141077 on GenesisL1: 3D structure, binding…

PDB: 5YVJ
Type: protein
Length: 604 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein
UniProt: F8TEL4, Q2YHE8
Pockets: 4 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 25% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Genome polyprotein	protein	589	25% helix, 25% strand	F8TEL4
C	Genome polyprotein	protein	15	0% helix, 47% strand	Q2YHE8

Ligands and binding sites

GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1110	0.82	0.83	91	empty
2	608	0.71	0.79	60	GOL
3	63	0.29	0.74	13	empty
4	61	0.27	0.74	16	empty

Interfaces

1 interface between chains.

B–C · 1134 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

5YVJ · Crystal structure of full length NS2B47-NS3 (gD4NS2BNS3) from Dengue virus 4 in open… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F8TEL4
Every structure of UniProt Q2YHE8
Elsewhere: RCSB PDB 5YVJ · PDBe 5YVJ · UniProt F8TEL4 · UniProt Q2YHE8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.