MolNFT v1 · #140918 · protein

Crystal structure of the second starkin domain of LAM4

5YQP · Membrane-anchored lipid-binding protein LAM4: “Crystal structure of the second starkin domain of LAM4”. X-ray diffraction, 3 pockets (best druggability 0.75). MolNFT v1 #140918 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 5YQP
Type: protein
Length: 370 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Membrane-anchored lipid-binding protein LAM4
UniProt: P38800
Pockets: 3 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Membrane-anchored lipid-binding protein LAM4	protein	185	26% helix, 35% strand	P38800

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	595	0.75	0.82	68	empty
2	288	0.68	0.83	35	empty
3	219	0.53	0.77	31	empty

Interfaces

1 interface between chains.

A–B · 451 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

5YQP · Crystal structure of the second StARkin domain of Lam4 · the same entry in another collection · chain A against A, TM-score 1.00
P38800 · AlphaFold monomer V2.0 prediction for membrane-anchored lipid-binding protein LAM4… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38800
Elsewhere: RCSB PDB 5YQP · PDBe 5YQP · UniProt P38800

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