MolNFT v1 · #14081 · protein

NMR structure of BCL-xl, an inhibitor of programmed cell death, minimized average structure

1LXL: “NMR structure of BCL-xl, an inhibitor of programmed cell death, minimized average structure”. Solution nmr, 3 pockets (best druggability 0.40). MolNFT v1 #14081 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1LXL
Type: protein
Length: 221 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BCL-xl
UniProt: Q07817
Pockets: 3 · best druggability 0.40

Structure

solution nmr · 1 distinct chain · 42% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	BCL-xl	protein	221	42% helix, 0% strand	Q07817

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.40	0.81	12	empty
2	61	0.29	0.74	19	empty
3	50	0.24	0.72	19	empty

Compared structures

1LXL · NMR structure of BCL-xl, an inhibitor of programmed cell death, minimized average… · the same entry in another collection · chain A against A, TM-score 1.00
Q07817 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q07817) · a predicted model of the same protein · chain A against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07817
Elsewhere: RCSB PDB 1LXL · PDBe 1LXL · UniProt Q07817

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