MolNFT v1 · #140381 · protein

MAP2K7 mutant -C218S

5Y90 · Dual specificity mitogen-activated protein kinase kinase 7: “MAP2K7 mutant -C218S”. X-ray diffraction, 2 pockets (best druggability 0.72). MolNFT v1 #140381 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5Y90
Type: protein
Length: 304 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dual specificity mitogen-activated protein kinase kinase 7
EC: 2.7.12.2
UniProt: O14733
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2)	protein	304	40% helix, 17% strand	O14733

Ligands and binding sites

GOL · Glycerol · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	346	0.72	0.84	42	empty
2	67	0.31	0.74	12	empty

Compared structures

5Y90 · MAP2K7 mutant -C218S · the same entry in another collection · chain A against A, TM-score 1.00
O14733 · AlphaFold monomer V2.0 prediction for dual specificity mitogen- activated protein kinase… · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14733
Elsewhere: RCSB PDB 5Y90 · PDBe 5Y90 · UniProt O14733

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