MolNFT v1 · #14038 · protein

Crystal structure of myotubularin-related protein 2 complexed with phosphate

1LW3: “Crystal structure of myotubularin-related protein 2 complexed with phosphate”. X-ray diffraction, 1 ligand (PO4), 6 pockets (best druggability 0.70). MolNFT v1 #14038 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1LW3
Type: protein
Length: 513 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myotubularin-related protein 2
EC: 3.1.3.64
UniProt: Q13614
Ligands: PO4
Pockets: 6 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myotubularin-related protein 2 (EC 3.1.3.64)	protein	513	38% helix, 17% strand	Q13614

Ligands and binding sites

PO4 · Phosphate ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	263	0.70	0.85	31	empty
2	51	0.56	0.90	18	empty
3	193	0.53	0.78	21	empty
4	188	0.46	0.75	24	empty
5	106	0.43	0.78	25	PO4

Compared structures

1LW3 · Crystal Structure of Myotubularin-related protein 2 complexed with phosphate · the same entry in another collection · chain A against A, TM-score 1.00
Q13614 · AlphaFold monomer V2.0 prediction for myotubularin-related protein 2 (Q13614) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13614
Elsewhere: RCSB PDB 1LW3 · PDBe 1LW3 · UniProt Q13614

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