MolNFT v1 · #140368 · protein
Mycobacterium tuberculosis 3-hydroxyisobutyrate dehydrogenase (mthibadh) + NAD + (R)-3-hydroxyisobutyrate (R-hiba)
5Y8M: “Mycobacterium tuberculosis 3-hydroxyisobutyrate dehydrogenase (mthibadh) + NAD + (R)-3-hydroxyisobutyrate…”. X-ray diffraction, 4 ligands (9ON, AKR, NAD). MolNFT v1 #140368 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5Y8M
- Type
- protein
- Length
- 578 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P9WNY5
- Ligands
- 9ON, AKR, NAD, HIU
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 289 | — | P9WNY5 |
| B | — | protein | 289 | — | P9WNY5 |
Ligands and binding sites
- 9ON · (2~{S})-2-methylpentanedioic acid · ligand · 2 copies · chains A, B
- AKR · Acrylic acid · ligand · chains A
- NAD · Nicotinamide-adenine-dinucleotide · ligand · chains B
- HIU · (2R)-3-hydroxy-2-methylpropanoic acid · ligand · chains A, B
- GOL · Glycerol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5Y8M · Mycobacterium tuberculosis 3-Hydroxyisobutyrate dehydrogenase (MtHIBADH) + NAD +… · the same entry in another collection · chain A against A, TM-score 1.00
- P9WNY5 · AlphaFold monomer V2.0 prediction for probable 3-hydroxyisobutyrate dehydrogenase (P9WNY5) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P9WNY5
- Elsewhere: RCSB PDB 5Y8M · PDBe 5Y8M · UniProt P9WNY5
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