MolNFT v1 · #140266 · protein
Crystal structure of EST1 and CDC13
5Y5A · KLLA0F20702P: “Crystal structure of EST1 and CDC13”. X-ray diffraction, 7 pockets (best druggability 0.58). MolNFT v1 #140266 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5Y5A
- Type
- protein
- Length
- 531 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- KLLA0F20702P; KLLA0F20922P
- UniProt
- Q6CJ80, Q6CJ70
- Pockets
- 7 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | KLLA0F20702P | protein | 514 | 70% helix, 3% strand | Q6CJ80 |
| B | KLLA0F20922P | protein | 17 | 0% helix, 0% strand | Q6CJ70 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 150 | 0.58 | 0.82 | 22 | empty |
| 2 | 285 | 0.55 | 0.76 | 35 | empty |
| 3 | 118 | 0.49 | 0.79 | 19 | empty |
| 4 | 203 | 0.45 | 0.73 | 31 | empty |
| 5 | 91 | 0.40 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1076 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 5Y5A · Crystal structure of Est1 and Cdc13 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6CJ80
- Every structure of UniProt Q6CJ70
- Elsewhere: RCSB PDB 5Y5A · PDBe 5Y5A · UniProt Q6CJ80 · UniProt Q6CJ70
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