Crystal structure of hetero-trimeric core of lubac: hoip double-uba complexed with hoil-1L ubl and sharpin ubl

Structure

x-ray diffraction · 3 distinct chains · 50% helix, 16% strand (DSSP).

Ligands and binding sites

• GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

3 interfaces between chains.

• A–B · 1708 Ų buried · 22 hydrogen bonds · protein-protein
• A–C · 1621 Ų buried · 14 hydrogen bonds · protein-protein
• B–C · 1285 Ų buried · 16 hydrogen bonds · protein-protein

Compared structures

• 5Y3T · Crystal structure of hetero-trimeric core of LUBAC: HOIP double-UBA complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
• Q91WA6 · AlphaFold monomer V2.0 prediction for sharpin (Q91WA6) · a predicted model of the same protein · chain C against A, TM-score 0.95
• Q924T7 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase RNF31 (Q924T7) · a predicted model of the same protein · chain B against A, TM-score 0.89
• Q9WUB0 · AlphaFold monomer V2.0 prediction for ranbp-type and C3HC4-type zinc finger-containing… · a predicted model of the same protein · chain A against A, TM-score 0.60

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9WUB0
• Every structure of UniProt Q924T7
• Every structure of UniProt Q91WA6
• Elsewhere: RCSB PDB 5Y3T · PDBe 5Y3T · UniProt Q9WUB0 · UniProt Q924T7 · UniProt Q91WA6