MolNFT v1 · #140139 · protein
Crystal structure of human DUSP28
5Y15 · Dual specificity phosphatase 28: “Crystal structure of human DUSP28”. X-ray diffraction, 1 ligand (PO4), 2 pockets (best druggability 0.47). MolNFT v1 #140139 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5Y15
- Type
- protein
- Length
- 291 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dual specificity phosphatase 28
- EC
- 3.1.3.16, 3.1.3.48
- UniProt
- Q4G0W2
- Ligands
- PO4
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dual specificity phosphatase 28 (EC 3.1.3.16, 3.1.3.48) | protein | 148 | 43% helix, 16% strand | Q4G0W2 |
| B | Dual specificity phosphatase 28 (EC 3.1.3.16, 3.1.3.48) | protein | 143 | 48% helix, 17% strand | Q4G0W2 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 69 | 0.47 | 0.83 | 18 | empty |
| 2 | 92 | 0.35 | 0.75 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 657 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4G0W2
- Elsewhere: RCSB PDB 5Y15 · PDBe 5Y15 · UniProt Q4G0W2
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