MolNFT v1 · #140006 · protein + RNA
Electron cryo-microscopy structure of LBUCAS13A-crrna binary complex
5XWY · A type VI-a CRISPR-CAS RNA-guided RNA ribonuclease, CAS13A: “Electron cryo-microscopy structure of LBUCAS13A-crrna binary complex”. Electron microscopy, 20 pockets (best druggability 0.89). MolNFT v1 #140006 on GenesisL1: 3D…
- PDB
- 5XWY
- Type
- protein + RNA
- Length
- 1,168 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- A type VI-a CRISPR-CAS RNA-guided RNA ribonuclease, CAS13A; RNA (59-mer)
- UniProt
- C7NBY4
- Pockets
- 20 · best druggability 0.89
Structure
electron microscopy · 2 distinct chains · 55% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | A type VI-a CRISPR-CAS RNA-guided RNA ribonuclease, CAS13A | protein | 1117 | 55% helix, 4% strand | C7NBY4 |
| B | RNA (59-mer) | rna | 51 | — | — |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 903 | 0.89 | 0.92 | 88 | empty |
| 2 | 691 | 0.77 | 0.82 | 62 | empty |
| 3 | 154 | 0.76 | 0.93 | 25 | empty |
| 4 | 452 | 0.72 | 0.82 | 57 | empty |
| 5 | 69 | 0.71 | 0.97 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 5927 Ų buried · 104 hydrogen bonds · protein-nucleic
Compared structures
- 5XWY · Electron cryo-microscopy structure of LbuCas13a-crRNA binary complex · the same entry in another collection · chain A against A, TM-score 1.00
- C7NBY4 · AlphaFold monomer V2.0 prediction for CRISPR-associated endoribonuclease CAS13A (C7NBY4) · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C7NBY4
- Elsewhere: RCSB PDB 5XWY · PDBe 5XWY · UniProt C7NBY4
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