MolNFT v1 · #140005 · protein

Crystal structure of the four N-terminal immunoglogulin domains of sidekick-1 protein

5XWX · Protein sidekick-1: “Crystal structure of the four N-terminal immunoglogulin domains of sidekick-1 protein”. X-ray diffraction, 9 pockets (best druggability 0.74). MolNFT v1 #140005 on GenesisL1: 3D structure, binding sites and…

PDB: 5XWX
Type: protein
Length: 752 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein sidekick-1
UniProt: Q3UH53
Pockets: 9 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protein sidekick-1	protein	376	5% helix, 52% strand	Q3UH53

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	509	0.74	0.82	58	empty
2	166	0.57	0.81	24	empty
3	231	0.52	0.76	27	empty
4	151	0.51	0.79	23	empty
5	219	0.50	0.75	25	empty

Interfaces

1 interface between chains.

A–B · 1147 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

5XWX · Crystal structure of the four N-terminal immunoglogulin domains of Sidekick-1 protein · the same entry in another collection · chain A against A, TM-score 1.00
Q3UH53 · AlphaFold monomer V2.0 prediction for protein sidekick-1 (Q3UH53) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q3UH53
Elsewhere: RCSB PDB 5XWX · PDBe 5XWX · UniProt Q3UH53

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