MolNFT v1 · #139978 · protein
Crystal structure of cystathionine beta-synthase from bacillus anthracis
5XW3 · O-acetylserine lyase: “Crystal structure of cystathionine beta-synthase from bacillus anthracis”. X-ray diffraction, 5 pockets (best druggability 0.58). MolNFT v1 #139978 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5XW3
- Type
- protein
- Length
- 525 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- O-acetylserine lyase
- UniProt
- Q81LL5
- Pockets
- 5 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | O-acetylserine lyase | protein | 265 | 42% helix, 20% strand | Q81LL5 |
| B | O-acetylserine lyase | protein | 260 | 41% helix, 21% strand | Q81LL5 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 245 | 0.58 | 0.78 | 30 | empty |
| 2 | 200 | 0.56 | 0.80 | 32 | empty |
| 3 | 183 | 0.54 | 0.79 | 28 | empty |
| 4 | 54 | 0.34 | 0.78 | 21 | empty |
| 5 | 56 | 0.28 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1535 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 5XW3 · Crystal structure of cystathionine beta-synthase from Bacillus anthracis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q81LL5
- Elsewhere: RCSB PDB 5XW3 · PDBe 5XW3 · UniProt Q81LL5
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