MolNFT v1 · #139909 · protein
Structure of the membrane fusion protein SPR0693 from streptococcus pneumoniae R6
5XU0 · Membrane-fusion protein: “Structure of the membrane fusion protein SPR0693 from streptococcus pneumoniae R6”. X-ray diffraction, 6 pockets (best druggability 0.71). MolNFT v1 #139909 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5XU0
- Type
- protein
- Length
- 681 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Membrane-fusion protein
- UniProt
- A0A0Y3EE53
- Pockets
- 6 · best druggability 0.71
Structure
x-ray diffraction · 3 distinct chains · 30% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Membrane-fusion protein | protein | 227 | 30% helix, 30% strand | A0A0Y3EE53 |
| B | Membrane-fusion protein | protein | 231 | 29% helix, 33% strand | A0A0Y3EE53 |
| C | Membrane-fusion protein | protein | 223 | 30% helix, 33% strand | A0A0Y3EE53 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.71 | 0.95 | 17 | empty |
| 2 | 460 | 0.66 | 0.78 | 44 | empty |
| 3 | 462 | 0.64 | 0.77 | 44 | empty |
| 4 | 52 | 0.52 | 0.87 | 15 | empty |
| 5 | 252 | 0.48 | 0.73 | 36 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1378 Ų buried · 24 hydrogen bonds · protein-protein
- B–C · 1343 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 modified (engineered).
Compared structures
- 5XU0 · Structure of the membrane fusion protein Spr0693 from Streptococcus pneumoniae R6 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0Y3EE53
- Elsewhere: RCSB PDB 5XU0 · PDBe 5XU0 · UniProt A0A0Y3EE53
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