MolNFT v1 · #13989 · protein
Crystal structure of the musk tyrosine kinase: insights into receptor autoregulation
1LUF · Muscle-specific tyrosine kinase receptor musk: “Crystal structure of the musk tyrosine kinase: insights into receptor autoregulation”. X-ray diffraction, 2 pockets (best druggability 0.64). MolNFT v1 #13989 on GenesisL1: 3D…
- PDB
- 1LUF
- Type
- protein
- Length
- 275 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Muscle-specific tyrosine kinase receptor musk
- EC
- 2.7.1.112
- UniProt
- Q62838
- Pockets
- 2 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Muscle-specific tyrosine kinase receptor musk (EC 2.7.1.112) | protein | 275 | 44% helix, 16% strand | Q62838 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 270 | 0.64 | 0.81 | 48 | empty |
| 2 | 154 | 0.60 | 0.83 | 23 | empty |
Compared structures
- 1LUF · Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation · the same entry in another collection · chain A against A, TM-score 1.00
- Q62838 · AlphaFold monomer V2.0 prediction for muscle, skeletal receptor tyrosine protein kinase… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62838
- Elsewhere: RCSB PDB 1LUF · PDBe 1LUF · UniProt Q62838
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