MolNFT v1 · #139849 · protein

Structure of coxsackievirus A6 (CVA6) virus procapsid particle

5XS5 · Genome polyprotein: “Structure of coxsackievirus A6 (CVA6) virus procapsid particle”. Electron microscopy, 8 pockets (best druggability 0.71). MolNFT v1 #139849 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5XS5
Type: protein
Length: 611 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein
UniProt: A0A0K2BNC7
Pockets: 8 · best druggability 0.71

Structure

electron microscopy · 3 distinct chains · 10% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Genome polyprotein	protein	211	8% helix, 29% strand	A0A0K2BNC7
B	Genome polyprotein	protein	193	11% helix, 38% strand	A0A0K2BNC7
C	Genome polyprotein	protein	207	10% helix, 33% strand	A0A0K2BNC7

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	329	0.71	0.84	56	empty
2	221	0.61	0.81	26	empty
3	184	0.43	0.73	28	empty
4	64	0.43	0.82	19	empty
5	59	0.39	0.80	18	empty

Interfaces

3 interfaces between chains.

A–C · 2600 Å² buried · 35 hydrogen bonds · protein-protein
A–B · 1600 Å² buried · 21 hydrogen bonds · protein-protein
B–C · 1513 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

5XS5 · Structure of Coxsackievirus A6 (CVA6) virus procapsid particle · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0K2BNC7
Elsewhere: RCSB PDB 5XS5 · PDBe 5XS5 · UniProt A0A0K2BNC7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.